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Neuron Glia Biol. 2010 Feb;6(1):63-71. doi: 10.1017/S1740925X10000098. Epub 2010 Jun 22.

Can satellite glial cells be therapeutic targets for pain control?

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  • 1Department of Anatomy, University of California, San Francisco, CA 94143-0452, USA.


Satellite glial cells (SGCs) undergo phenotypic changes and divide the following injury into a peripheral nerve. Nerve injury, also elicits an immune response and several antigen-presenting cells are found in close proximity to SGCs. Silencing SCG-specific molecules involved in intercellular transport (Connexin 43) or glutamate recycling (glutamine synthase) can dramatically alter nociceptive responses of normal and nerve-injured rats. Transducing SGCs with glutamic acid decarboxylase can produce analgesia in models of trigeminal pain. Taken together these data suggest that SGCs may play a role in the genesis or maintenance of pain and open a range of new possibilities for curing neuropathic pain.

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