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Chem Biodivers. 2010 Jun;7(6):1555-62. doi: 10.1002/cbdv.200900283.

New biological functions and applications of high-molecular-mass poly-gamma-glutamic acid.

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  • 1KRIBB, 52 Oun-dong, Yuseong-gu, Daejeon 305-806, Korea.


Ultra-high-molecular-weight poly-gamma-glutamic acid (gamma-PGA) is a most promising biodegradable polymer that is produced by Bacillus subtilis (chungkookjang). Attractive properties of gamma-PGA are that it is water soluble, anionic, biodegradable, and edible. Development of gamma-PGA has pursued in terms of cosmetics/skin care, bone care, nanoparticle for drug delivery system, hydrogel, and so on. Very recently, our research has shown that gamma-PGA can be used as an immune-stimulating agent, especially at high molecular weight. This review presents the synthesis and production of high-molecular-weight gamma-PGA and its various applications in industrial fields.

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