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J Neurooncol. 2011 Feb;101(3):509-11. doi: 10.1007/s11060-010-0268-8. Epub 2010 Jun 20.

Prolonged survival of neoplastic meningitis from breast cancer with letrozole and intrathecal methotrexate: a case report.

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  • 1Department of Medical Oncology, School of Medicine, University of Patras, 26504 Rio, Patras, Greece.


Neoplastic meningitis from breast cancer has a dismal prognosis and short survival. Treatment is based on the intrathecal administration of chemotherapeutic agents, cranial or craniospinal radiotherapy, and systemic chemotherapy. In this report we describe the case of a woman with neoplastic meningitis from breast carcinoma who developed an excellent response to letrozole combined with intrathecal methotrexate, resulting in long-term survival of more than 36 months. Based on the findings of this case report, we suggest that addition of letrozole to the standard therapeutic approach may be beneficial for some patients.

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