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Curr Opin Pharmacol. 2010 Aug;10(4):380-4. doi: 10.1016/j.coph.2010.05.002. Epub 2010 Jun 17.

New models for cancer research: human cancer stem cell xenografts.

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  • 1Dipartimento Ematologia, Oncologia e Medicina Molecolare, Istituto Superiore di Sanità, Viale Regina Elena 299, Roma, Italy.


Human cancer stem cells represent promising tools for new approaches to pathway-targeted drug discovery and preclinical screening. Because of their distinctive capability to recapitulate the development of the original tumors in vivo, the study of human cancer stem cells (CSCs) largely relies on models of xenograft transplantation into immunodeficient mice. In this frame, immunity and microenvironment-related issues need careful consideration. Here we shortly revise present knowledge on xenograft-related aspects of human CSCs studies.

Copyright 2010 Elsevier Ltd. All rights reserved.

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