J Clin Psychopharmacol. 1991 Apr;11(2):116-20.

A preliminary trial of fluoxetine in refractory borderline patients.

Cornelius JR, Soloff PH, Perel JM, Ulrich RF.

Source

Department of Psychiatry, University of Pittsburgh, Pennsylvania 15213.

Abstract

Borderline personality disorder is characterized by many of the symptoms associated with serotonin dysregulation, including affective lability, suicidal behaviors, and impulsive aggression. These provide an ideal clinical model for studying the treatment of these serious symptom presentations. The recent development of selective serotonin reuptake inhibitors such as fluoxetine makes it possible to study the role of serotonin in the etiology of affective and behavioral dyscontrol in borderline personality disorder. In this preliminary medication trial, 5 borderline personality disorder patients with severe symptoms resistant to phenelzine and neuroleptics were treated openly with fluoxetine 20 to 40 mg for 8 weeks, with weekly ratings of symptoms. The findings from this work suggested efficacy for fluoxetine in treating the depressive and impulsive symptoms of refractory patients with borderline personality disorder.

PMID:: 2056138; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

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MeSH Terms

Substances

Fluoxetine

Grant Support

MH-30915/MH/NIMH NIH HHS/United States

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Ovid Technologies, Inc.

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FLUOXETINE - HSDB

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Related citations in PubMed

Fluoxetine trial in borderline personality disorder. [Psychopharmacol Bull. 1990]
Fluoxetine trial in borderline personality disorder.
Cornelius JR, Soloff PH, Perel JM, Ulrich RF. Psychopharmacol Bull. 1990; 26(1):151-4.
A preliminary, randomized trial of fluoxetine, olanzapine, and the olanzapine-fluoxetine combination in women with borderline personality disorder. [J Clin Psychiatry. 2004]
A preliminary, randomized trial of fluoxetine, olanzapine, and the olanzapine-fluoxetine combination in women with borderline personality disorder.
Zanarini MC, Frankenburg FR, Parachini EA. J Clin Psychiatry. 2004 Jul; 65(7):903-7.
Efficacy of phenelzine and haloperidol in borderline personality disorder. [Arch Gen Psychiatry. 1993]
Efficacy of phenelzine and haloperidol in borderline personality disorder.
Soloff PH, Cornelius J, George A, Nathan S, Perel JM, Ulrich RF. Arch Gen Psychiatry. 1993 May; 50(5):377-85.
Review [Borderline personality disorder, self-mutilation and suicide: literature review]. [Encephale. 2008]
Review [Borderline personality disorder, self-mutilation and suicide: literature review].
Oumaya M, Friedman S, Pham A, Abou Abdallah T, Guelfi JD, Rouillon F. Encephale. 2008 Oct; 34(5):452-8. Epub 2008 Feb 20.
Review Impulsive aggression in borderline personality disorder. [Curr Psychiatry Rep. 2000]
Review Impulsive aggression in borderline personality disorder.
Goodman M, New A. Curr Psychiatry Rep. 2000 Feb; 2(1):56-61.

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Cited by 1 PubMed Central article

Tryptophan-hydroxylase 2 haplotype association with borderline personality disorder and aggression in a sample of patients with personality disorders and healthy controls. [J Psychiatr Res. 2010]
Tryptophan-hydroxylase 2 haplotype association with borderline personality disorder and aggression in a sample of patients with personality disorders and healthy controls.
Perez-Rodriguez MM, Weinstein S, New AS, Bevilacqua L, Yuan Q, Zhou Z, Hodgkinson C, Goodman M, Koenigsberg HW, Goldman D, et al. J Psychiatr Res. 2010 Nov; 44(15):1075-81. Epub 2010 May 6.

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