Planta Med. 2011 Jan;77(1):54-6. Epub 2010 Jun 17.

Tea tree oil might combat melanoma.

Bozzuto G, Colone M, Toccacieli L, Stringaro A, Molinari A.

Source

Department of Technology and Health, Istituto Superiore di Sanità, Rome, Italy.

Abstract

In this study we present new data from experiments focused on the antitumor activity of tea tree oil (TTO), an essential oil distilled from Melaleuca alternifolia. TTO proved to be capable of inhibiting the growth of melanoma cells and of overcoming multidrug resistance (MDR), as we reported in our previous study. Moreover, the survival role of the MDR-marker P-glycoprotein appears to be involved in the mechanism of invasion of melanoma cells. The results reported herein indicate that TTO and its main active component, terpinen-4-ol, can also interfere with the migration and invasion processes of drug-sensitive and drug-resistant melanoma cells.

PMID:: 20560116; [PubMed - indexed for MEDLINE]

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Terpinen-4-ol, the main component of Melaleuca alternifolia (tea tree) oil inhibits the in vitro growth of human melanoma cells. [J Invest Dermatol. 2004]
Terpinen-4-ol, the main component of Melaleuca alternifolia (tea tree) oil inhibits the in vitro growth of human melanoma cells.
Calcabrini A, Stringaro A, Toccacieli L, Meschini S, Marra M, Colone M, Salvatore G, Mondello F, Arancia G, Molinari A. J Invest Dermatol. 2004 Feb; 122(2):349-60.
Induction of necrosis and cell cycle arrest in murine cancer cell lines by Melaleuca alternifolia (tea tree) oil and terpinen-4-ol. [Cancer Chemother Pharmacol. 2010]
Induction of necrosis and cell cycle arrest in murine cancer cell lines by Melaleuca alternifolia (tea tree) oil and terpinen-4-ol.
Greay SJ, Ireland DJ, Kissick HT, Levy A, Beilharz MW, Riley TV, Carson CF. Cancer Chemother Pharmacol. 2010 Apr; 65(5):877-88. Epub 2009 Aug 13.
Interaction of tea tree oil with model and cellular membranes. [J Med Chem. 2006]
Interaction of tea tree oil with model and cellular membranes.
Giordani C, Molinari A, Toccacieli L, Calcabrini A, Stringaro A, Chistolini P, Arancia G, Diociaiuti M. J Med Chem. 2006 Jul 27; 49(15):4581-8.
Review A review of the toxicity of Melaleuca alternifolia (tea tree) oil. [Food Chem Toxicol. 2006]
Review A review of the toxicity of Melaleuca alternifolia (tea tree) oil.
Hammer KA, Carson CF, Riley TV, Nielsen JB. Food Chem Toxicol. 2006 May; 44(5):616-25. Epub 2005 Oct 21.
Review Safety, efficacy and provenance of tea tree (Melaleuca alternifolia) oil. [Contact Dermatitis. 2001]
Review Safety, efficacy and provenance of tea tree (Melaleuca alternifolia) oil.
Carson CF, Riley TV. Contact Dermatitis. 2001 Aug; 45(2):65-7.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Tea tree oil might combat melanoma.
Tea tree oil might combat melanoma.
Planta Med. 2011 Jan ;77(1):54-6. Epub 2010 Jun 17 .

PubMed
Ellagic acid, a natural polyphenolic compound, induces apoptosis and potentiates...
Ellagic acid, a natural polyphenolic compound, induces apoptosis and potentiates retinoic acid-induced differentiation of human leukemia HL-60 cells.
Int J Hematol. 2010 Jul ;92(1):136-43. Epub 2010 Jun 18 .

PubMed
CYP1A2 polymorphisms, occupational and environmental exposures and risk of bladd...
CYP1A2 polymorphisms, occupational and environmental exposures and risk of bladder cancer.
Eur J Epidemiol. 2010 Jul ;25(7):491-500. Epub 2010 Jun 18 .

PubMed
Defective lamin A-Rb signaling in Hutchinson-Gilford Progeria Syndrome and rever...
Defective lamin A-Rb signaling in Hutchinson-Gilford Progeria Syndrome and reversal by farnesyltransferase inhibition.
PLoS One. 2010 Jun 15 ;5(6):e11132.

PubMed
Actin disassembly 'clock' and membrane tension determine cell shape and turning:...
Actin disassembly 'clock' and membrane tension determine cell shape and turning: a mathematical model.
J Phys Condens Matter. 2010 May 19 ;22(19):194118.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: