Send to:

Choose Destination
See comment in PubMed Commons below
Gut Liver. 2010 Jun;4(2):151-60. doi: 10.5009/gnl.2010.4.2.151. Epub 2010 Jun 16.

Hereditary colon cancer: lynch syndrome.

Author information

  • 1Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, USA.


Lynch syndrome is the most common familial colorectal cancer syndrome. It is linked to germline mutations in one of four DNA mismatch repair (MMR) genes. A comprehensive family history is one important way to identify at-risk individuals. The elucidation of the molecular genetics of this syndrome has made it possible to screen for the disorder with molecular tests. Microsatellite instability and/or immunohistochemistry followed by germline testing for mutations in MMR genes is now a standard approach for clinically suspected cases. Correctly recognizing Lynch syndrome is essential for the application of appropriate screening and surveillance measures. Close surveillance and risk-reducing operations can decrease cancer-related mortality. In addition, counseling is an important component of the management of any family with Lynch syndrome.


Colon cancer; Hereditary nonpolyposis colon cancer; Immunohistochemistry; Lynch syndrome; Microsatellite instability; Mismatch repair gene

Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Inforang Icon for PubMed Central
    Loading ...
    Write to the Help Desk