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Cold Spring Harb Perspect Biol. 2010 Aug;2(8):a000612. doi: 10.1101/cshperspect.a000612. Epub 2010 Jun 16.

The budding yeast nucleus.

Author information

  • 1UMR 218, Centre National de la Recherche Scientifique, 26 rue d'Ulm, 75231 Paris Cedex 05, France.

Abstract

The budding yeast nucleus, like those of other eukaryotic species, is highly organized with respect to both chromosomal sequences and enzymatic activities. At the nuclear periphery interactions of nuclear pores with chromatin, mRNA, and transport factors promote efficient gene expression, whereas centromeres, telomeres, and silent chromatin are clustered and anchored away from pores. Internal nuclear organization appears to be function-dependent, reflecting localized sites for tRNA transcription, rDNA transcription, ribosome assembly, and DNA repair. Recent advances have identified new proteins involved in the positioning of chromatin and have allowed testing of the functional role of higher-order chromatin organization. The unequal distribution of silent information regulatory factors and histone modifying enzymes, which arises in part from the juxtaposition of telomeric repeats, has been shown to influence chromatin-mediated transcriptional repression. Other localization events suppress unwanted recombination. These findings highlight the contribution budding yeast genetics and cytology have made to dissecting the functional role of nuclear structure.

PMID:
20554704
[PubMed - indexed for MEDLINE]
PMCID:
PMC2908769
Free PMC Article
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