Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Schizophr Res. 2010 Aug;121(1-3):46-54. doi: 10.1016/j.schres.2010.05.014. Epub 2010 Jun 9.

Structural brain alterations in schizophrenia following fetal exposure to the inflammatory cytokine interleukin-8.

Author information

  • 1Department of Psychology, Temple University, Philadelphia, PA 19122-6085, United States. ellman@temple.edu

Abstract

BACKGROUND:

Maternal infection during pregnancy has been repeatedly associated with increased risk for schizophrenia. Nevertheless, most viruses do not cross the placenta; therefore, the damaging effects to the fetus appear to be related to maternal antiviral responses to infection (e.g. proinflammatory cytokines). Fetal exposure to the proinflammatory cytokine interleukin-8 (IL-8) has been significantly associated with risk of schizophrenia in offspring. This study sought to determine the association between fetal exposure to IL-8 and structural brain changes among schizophrenia cases and controls.

METHODS:

Subjects were 17 cases diagnosed with schizophrenia from the Developmental Insult and Brain Anomaly in Schizophrenia (DIBS) study. Psychiatric diagnoses were determined among offspring with semi-structured interviews and medical records review. IL-8 was determined from assays in archived prenatal sera and volumetric analyses of neuroanatomical regions were obtained from T1-weighted magnetic resonance imaging in adulthood. Eight controls were included for exploratory purposes.

RESULTS:

Among cases, fetal exposure to increases in IL-8 was associated with significant increases in ventricular cerebrospinal fluid, significant decreases in left entorhinal cortex volumes and significant decreases in right posterior cingulate volumes. Decreases that approached significance also were found in volumes of the right caudate, the putamen (bilaterally), and the right superior temporal gyrus. No significant associations were observed among controls.

CONCLUSION:

Fetal exposure to elevations in maternal IL-8 led to structural neuroanatomic alterations among cases in regions of the brain consistently implicated in schizophrenia research. In utero exposure to elevations in IL-8 may partially account for brain disturbances commonly found in schizophrenia.

Copyright 2010 Elsevier B.V. All rights reserved.

Comment in

PMID:
20553865
[PubMed - indexed for MEDLINE]
PMCID:
PMC2910151
Free PMC Article

Images from this publication.See all images (3)Free text

Figure 3
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk