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    J Pediatr. 2010 Aug;157(2):334-6. Epub 2010 May 31.

    Prophylactic phenobarbital and whole-body cooling for neonatal hypoxic-ischemic encephalopathy.

    Meyn DF Jr, Ness J, Ambalavanan N, Carlo WA.

    Source

    Department of Pediatrics, Division of Neonatology, University of Alabama at Birmingham, Birmingham, AL, USA. don.meyn@infamedics.com

    Abstract

    In infants with hypoxic-ischemic encephalopathy, cooling reduces death/neurodevelopmental impairment, whereas prophylactic anticonvulsants may not. This retrospective analysis shows no reduction in neurodevelopmental impairment (23% in prophylactic phenobarbital group vs 45% in controls, P = .3) but fewer clinical seizures in cooled infants who received prophylactic phenobarbital (15% vs 82% P < .0001).

    Copyright (c) 2010 Mosby, Inc. All rights reserved.

    PMID:
    20553847
    [PubMed - indexed for MEDLINE]

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