Physiology (Bethesda). 2010 Jun;25(3):176-85.

PPAR modulation of kinase-linked receptor signaling in physiology and disease.

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Center for Integrative Genomics, National Research Center Frontiers in Genetics, University of Lausanne, Lausanne, Switzerland.

Abstract

Kinase-linked receptors and nuclear receptors connect external cues to gene transcription. Among nuclear receptors, peroxisome proliferator-activated receptors (PPARs) are of special interest in relation to widespread human diseases. Mapping out connections between PPARs and kinase-linked receptor signaling is central to better understand physiological and pathophysiological processes and to better define therapeutic strategies. This is the aim of the present review.

PMID:: 20551231; [PubMed - indexed for MEDLINE]

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