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Antimicrob Agents Chemother. 2010 Sep;54(9):3980-4. doi: 10.1128/AAC.00046-10. Epub 2010 Jun 14.

Experimental murine scedosporiosis: histopathology and azole treatment.

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  • 1Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, Carrer Sant Llorenç, 21.43201 Reus, Spain.

Abstract

The histopathology of clinical isolates of Scedosporium apiospermum, Scedosporium boydii, and Scedosporium aurantiacum in immunosuppressed mice was evaluated. The organs most affected were the brain, kidneys, and spleen. S. aurantiacum produced more tissue damage than the other two species. Amphotericin B (AMB) was ineffective in the treatment of murine infections caused by such isolates, and posaconazole and voriconazole showed efficacy that correlated with the in vitro susceptibility data.

PMID:
20547805
[PubMed - indexed for MEDLINE]
PMCID:
PMC2935030
Free PMC Article
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