Int J Radiat Biol. 2010 Jul;86(7):542-7.

Ipsilateral breast tumour recurrence (IBTR) dynamics in breast conserving treatments with or without radiotherapy.

Demicheli R, Ardoino I, Boracchi P, Lozza L, Biganzoli E.

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Department of Medical Oncology, Università di Milano, Milano, Italy. demicheli@istitutotumori.mi.it

Abstract

Purpose: To study whether ipsilateral breast tumour recurrence (IBTR) dynamics are modified by post-operative radiotherapy (RT). Methods and materials: The hazard rate for IBTR was analysed in a database from patients undergoing breast conserving surgery with or without post-operative radiotherapy within randomised clinical trials from the Milan Cancer Institute. Results: The hazard rate for IBTR presents a bimodal pattern. Post-operative radiotherapy, in addition to reducing IBTR incidence from 24.5% to 5.8% at 10 years, causes more than a one year delay in its clinical manifestation. Distant metastasis dynamics are not modified by radiotherapy administration. Conclusions: In the light of a biology-based model of breast cancer metastasis development, IBTR peak delay most likely originates in a more prolonged dormancy time that, in turn, is related to local microenvironment conditions. Present clinical findings suggest that, besides a direct killing effect on residual tumour cells, microenvironmental modifications may play a major role in RT effectiveness.

PMID:: 20545574; [PubMed - indexed for MEDLINE]

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Ipsilateral breast tumour recurrence (IBTR) dynamics in breast conserving treatments with or without radiotherapy.

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