Abstract
Inactivation of tumor suppressors and activation of protooncogenes are critical events in malignant cell transformation and tumor progression. Pdcd4 encodes a protein with tumor suppressor functions, which accounts for an increased interest to Pdcd4 as a potential diagnostic and prognostic marker, as well as a target for antineoplastic therapy. This review summarizes well-known properties and functions of Pdcd4 tumor suppressor and mechanisms of its regulation in tumor cells. It is also focused to the role of Pdcd4 in cellular transformation and tumor progression, as well as on its potential practical application in oncology.
Publication types
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English Abstract
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Apoptosis Regulatory Proteins / genetics
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Apoptosis Regulatory Proteins / metabolism*
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Apoptosis Regulatory Proteins / physiology
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Biomarkers, Tumor / genetics
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Biomarkers, Tumor / metabolism*
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Cell Proliferation
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Cell Transformation, Neoplastic / genetics
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Cell Transformation, Neoplastic / metabolism*
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Gene Expression Regulation, Neoplastic
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Humans
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Mice
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Neoplasms / genetics
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Neoplasms / metabolism*
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Neoplasms / therapy
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RNA-Binding Proteins / genetics
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RNA-Binding Proteins / metabolism*
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RNA-Binding Proteins / physiology
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Signal Transduction
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Tumor Suppressor Proteins / genetics
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Tumor Suppressor Proteins / metabolism*
Substances
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Apoptosis Regulatory Proteins
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Biomarkers, Tumor
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PDCD4 protein, human
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Pdcd4 protein, mouse
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RNA-Binding Proteins
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Tumor Suppressor Proteins