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Middle East Afr J Ophthalmol. 2010 Jan;17(1):60-2. doi: 10.4103/0974-9233.61218.

What is Central Toxic Keratopathy Syndrome if it is not Diffuse lamellar Keratitis Grade IV?

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  • 1Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA.


The Central Toxic Keratopathy (CTK) syndrome describes a rare, acute, self-limited, non-inflammatory process that yields central corneal opacification and significant hyperopic shift after refractive surgery. Despite being exceedingly rare, certain clinical features of CTK give the condition a striking resemblance to other more serious inflammatory conditions, including diffuse lamellar keratitis (DLK). As the authors demonstrate in this article, despite the overlapping clinical features, CTK is a disease process that is distinct from DLK and, therefore, in need of distinct management interventions.


Central toxic keratopathy; Laser in situ keratomileusis; PRK; diffuse lamellar keratitis; keratitis

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