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J Bacteriol. 2010 Sep;192(17):4517-21. doi: 10.1128/JB.00368-10. Epub 2010 Jun 11.

Genomic identification of a novel mutation in hfq that provides multiple benefits in evolving glucose-limited populations of Escherichia coli.

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  • 1School of Molecular Bioscience, University of Sydney, New South Wales, Australia.


Beneficial mutations in diversifying glucose-limited Escherichia coli populations are mostly unidentified. The genome of an evolved isolate with multiple differences from that of the ancestor was fully assembled. Remarkably, a single mutation in hfq was responsible for the multiple benefits under glucose limitation through changes in at least five regulation targets.

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