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    Vaccine. 2010 Jul 19;28(32):5245-53. Epub 2010 Jun 10.

    The potential value of Clostridium difficile vaccine: an economic computer simulation model.

    Lee BY, Popovich MJ, Tian Y, Bailey RR, Ufberg PJ, Wiringa AE, Muder RR.

    Source

    Applied Modeling, Public Health Computational and Operations Research Group (PHICOR), Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA 15213, USA. BYL1@pitt.edu

    Abstract

    Efforts are currently underway to develop a vaccine against Clostridium difficile infection (CDI). We developed two decision analytic Monte Carlo computer simulation models: (1) an Initial Prevention Model depicting the decision whether to administer C. difficile vaccine to patients at-risk for CDI and (2) a Recurrence Prevention Model depicting the decision whether to administer C. difficile vaccine to prevent CDI recurrence. Our results suggest that a C. difficile vaccine could be cost-effective over a wide range of C. difficile risk, vaccine costs, and vaccine efficacies especially, when being used post-CDI treatment to prevent recurrent disease.

    (c) 2010 Elsevier Ltd. All rights reserved.

    PMID:
    20541582
    [PubMed - indexed for MEDLINE]
    PMCID: PMC2908196
    Free PMC Article

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