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Early Interv Psychiatry. 2010 May;4(2):189-95. doi: 10.1111/j.1751-7893.2010.00174.x.

Is there an association between neurocognitive performance and medication adherence in first episode psychosis?

Author information

  • 1Douglas Mental Health University Institute and Department of Psychiatry, McGill University, MontrĂ©al, Canada. martin.lepage@mcgill.ca

Abstract

AIM:

Medication adherence is a determining factor for symptomatic remission and relapse prevention following a first episode of psychosis (FEP). Neurocognitive abilities have received only scant attention so far as a risk factor for poor adherence but significant impairments with memory and/or planning abilities could play a role. We examined early medication adherence following admission to a specialized clinical programme for FEP.

METHOD:

One hundred sixty FEP participants and 35 healthy controls completed an exhaustive neurocognitive assessment. FEP participants were categorized as a function of their medication adherence at 6 months into poor (n = 34), partial (n = 27) and full (n = 99) adherence, respectively. Domain-specific and global measures of cognitive ability were examined.

RESULTS:

No measure of neurocognition could significantly discriminate amongst the three medication adherence groups.

CONCLUSION:

These results suggest no strong associations between neurocognitive abilities and medication adherence in first episode of psychosis.

PMID:
20536976
[PubMed - indexed for MEDLINE]
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