Am J Psychiatry. 1991 Jul;148(7):933-5.

Technique for greatly shortening the transition from methadone to naltrexone maintenance of patients addicted to opiates.

Loimer N, Lenz K, Schmid R, Presslich O.

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Department of Psychiatry, University of Vienna, Austria.

Abstract

Acute methadone detoxification was induced by the intravenous administration of naloxone during simultaneous intravenous sedation with midazolam, a fully reversible short-acting benzodiazepine, in seven patients addicted to opiates. Within hours the patients tolerated full doses of naltrexone. This technique enables patients to transfer easily, quickly, and safely from methadone to naltrexone maintenance.

PMID:: 2053636; [PubMed - indexed for MEDLINE]

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Naloxone-precipitated withdrawal: a method for rapid induction onto naltrexone. [Clin Pharmacol Ther. 1977]
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Resnick RB, Kestenbaum RS, Washton A, Poole D. Clin Pharmacol Ther. 1977 Apr; 21(4):409-13.
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Cited by 2 PubMed Central articles

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Technique for greatly shortening the transition from methadone to naltrexone maintenance of patients addicted to opiates.

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