Format

Send to

Choose Destination
See comment in PubMed Commons below
J Cardiovasc Transl Res. 2010 Jun;3(3):241-5. doi: 10.1007/s12265-010-9168-8.

MicroRNA expression and function in cardiac ischemic injury.

Author information

  • 1Department of Neurosurgery, LSU Health Science Center, Shreveport, LA 71130, USA.

Abstract

Ischemic heart disease (IHD) or myocardial ischemia is one of the leading causes of mortality all over the world. There is a definite need for new approaches to improve therapies and diagnostics. The pathological process leading to IHD is associated with an altered expression of genes that are important for cardiac functions. Micro-RNAs (miRNAs) have emerged as one of the central players regulating gene expression via degradation or translational inhibition of their target genes. Increasing evidence indicates that miRNAs may serve as potential diagnostic biomarkers and innovative therapeutic targets in several human diseases including cardiovascular disease. Here, we review the latest advances in the identification and validation of myocardial ischemia-related miRNAs and their target genes and discuss the roles of specific miRNAs in regulating ischemia-related cardiac injury, including apoptosis, fibrosis, arrhythmia, and angiogenesis.

KEYWORDS:

Cardiac Ischemia/Reperfusion Injury; Gene Expression; MicroRNAs; Target Genes

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer Icon for PubMed Central
    Loading ...
    Write to the Help Desk