Comparison of BD Phoenix, Vitek 2, and MicroScan automated systems for detection and inference of mechanisms responsible for carbapenem resistance in Enterobacteriaceae

J Clin Microbiol. 2010 Aug;48(8):2999-3002. doi: 10.1128/JCM.00341-10. Epub 2010 Jun 9.

Abstract

We assessed the ability of three commercial systems to infer carbapenem resistance mechanisms in 39 carbapenemase-producing and 16 other carbapenem-resistant Enterobacteriaceae. The sensitivity/specificity values for "flagging" a likely carbapenemase were 100%/0% (BD Phoenix), 82 to 85%/6 to 19% (MicroScan), and 74%/38% (Vitek 2), respectively. OXA-48 producers were poorly detected, but all systems reliably detected isolates with KPC and most with metallo-carbapenemases.

Publication types

  • Comparative Study
  • Evaluation Study

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Automation / methods*
  • Bacterial Proteins / metabolism*
  • Carbapenems / pharmacology*
  • Enterobacteriaceae / drug effects*
  • Enterobacteriaceae / enzymology
  • Humans
  • Microbial Sensitivity Tests / methods
  • Sensitivity and Specificity
  • beta-Lactam Resistance*
  • beta-Lactamases / metabolism*

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Carbapenems
  • beta-Lactamases
  • carbapenemase