BMC Biol. 2010 May 11;8:53.

Hidden reach of the micromanagers.

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Regulus Therapeutics, 1896 Rutherford Road, Carlsbad, CA 92008, USA. plinsley@regulusrx.com

Abstract

Small interfering RNAs can trigger unintended, microRNA-like off-target effects, but the impact of these effects on functional studies has been controversial. A recent study in BMC Genomics shows that microRNA-like effects can predominate among the 'hits' of functional genomics screens.

PMID:: 20529236; [PubMed - indexed for MEDLINE]
PMCID: PMC2867781

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