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Allergy Asthma Clin Immunol. 2005 Dec 15;1(4):142-60. doi: 10.1186/1710-1492-1-4-142. Epub 2005 Dec 15.

Pediatric hemophagocytic syndromes: a diagnostic and therapeutic challenge.

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  • 1Division of Haematology and Oncology, Department of Paediatrics, Montreal Children's Hospital, McGill University Health Centre, Montreal, Quebec.


Pediatric hemophagocytic syndrome (HS) is a severe and often fatal clinical disorder. This syndrome is frequently unrecognized, and thus, affected children may receive suboptimal management, leading to an increase in mortality. The purpose of this review is to provide a clinical guide to (1) the recognition of HS based on clinical, biologic, and pathologic features; (2) the identification of the primary cause of HS in a given affected child; and (3) the initiation of effective treatment in a timely manner.

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