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Nat Genet. 2010 Jul;42(7):576-8. doi: 10.1038/ng.602. Epub 2010 Jun 6.

Common variants in FOXP1 are associated with generalized vitiligo.

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  • 1Human Medical Genetics Program, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA.

Abstract

In a recent genome-wide association study of generalized vitiligo, we identified ten confirmed susceptibility loci. By testing additional loci that showed suggestive association in the genome-wide study, using two replication cohorts of European descent, we observed replicated association of generalized vitiligo with variants at 3p13 encompassing FOXP1 (rs17008723, combined P=1.04x10(-8)) and with variants at 6q27 encompassing CCR6 (rs6902119, combined P=3.94x10(-7)).

PMID:
20526340
[PubMed - indexed for MEDLINE]
PMCID:
PMC2893242
Free PMC Article
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