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Allergy Asthma Clin Immunol. 2008 Mar 15;4(1):29-36. doi: 10.1186/1710-1492-4-1-29. Epub 2008 Mar 15.

Stress and childhood asthma risk: overlapping evidence from animal studies and epidemiologic research.

Author information

  • Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School and Department of Society, Human Development and Health, Harvard School of Public Health, Boston, MA. rosalind.wright@channing.harvard.edu.

Abstract

: Rapidly expanding evidence increasingly strengthens the evidence linking psychological factors to asthma and allergy expression. Parallel studies in animals and humans demonstrating the influence of prenatal maternal stress and early caregiving experiences on the disrupted regulation of defensive biological systems [eg, sympathetic and adrenomedullary (SAM) system and the hypothalamicpituitary-adrenocortical (HPA) axis] provide strong proof of concept for this line of research. The consequent altered neuroimmune responses may influence the expression of immune-mediated disorders such as asthma as well as enhance an individual's susceptibility to other environmental factors that may also contribute to asthma risk.

PMID:
20525123
[PubMed]
PMCID:
PMC2869338
Free PMC Article

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