Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
Expert Rev Respir Med. 2010 Jun;4(3):395-411. doi: 10.1586/ers.10.29.

Neurotrophins in lung health and disease.

Author information

  • 1Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. prakash.ys@mayo.edu


Neurotrophins (NTs) are a family of growth factors that are well-known in the nervous system. There is increasing recognition that NTs (nerve growth factor, brain-derived neurotrophic factor and NT3) and their receptors (high-affinity TrkA, TrkB and TrkC, and low-affinity p75NTR) are expressed in lung components including the nasal and bronchial epithelium, smooth muscle, nerves and immune cells. NT signaling may be important in normal lung development, developmental lung disease, allergy and inflammation (e.g., rhinitis, asthma), lung fibrosis and even lung cancer. In this review, we describe the current status of our understanding of NT signaling in the lung, with hopes of using aspects of the NT signaling pathway in the diagnosis and therapy of lung diseases.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Icon for Informa Healthcare Icon for PubMed Central
    Loading ...
    Write to the Help Desk