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    Antioxid Redox Signal. 2011 Jan 15;14(2):261-73. Epub 2010 Aug 30.

    Nonhuman primate models of human immunology.

    Messaoudi I, Estep R, Robinson B, Wong SW.

    Source

    Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon 97006, USA. messaoud@ohsu.edu

    Abstract

    Nonhuman primates have been used for biomedical research for several decades. The high level of genetic homology to humans coupled with their outbred nature has made nonhuman primates invaluable preclinical models. In this review, we summarize recent advances in our understanding of the nonhuman primate immune system, with special emphasis on studies carried out in rhesus macaque (Macaca mulatta). We highlight the utility of nonhuman primates in the characterization of immune senescence and the evaluation of new interventions to slow down the aging of the immune system.

    PMID:
    20524846
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC3014769
    Free PMC Article

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