Family-focused preventive intervention research could serve as an exemplar for the translation of science into practice on a scale that achieves public health impact. This article outlines advances in the field and translational research that still is needed, presenting these within a heuristic framework. The framework is designed to guide a broad translational research agenda fostering a shift toward a paradigm of public health impact-called a translational impact paradigm. Current advances and needed research in the subfield are mapped onto a set of four translational impact factors: effectiveness of interventions; extensiveness of their population coverage; efficiency of interventions; and engagement of eligible populations or organizations, including widespread adoption and sustained, quality implementation (the "4 Es" of intervention impact). The article then highlights key tasks required to progress in this area: improving practitioner-scientist partnership networks embedded in systems for delivery of evidence-based interventions; application of research guidelines and standards that facilitate translational impact; and policy change that supports needed research.