Format

Send to:

Choose Destination
See comment in PubMed Commons below
Thorax. 2010 Jun;65(6):516-22. doi: 10.1136/thx.2009.128256.

Effect of diet on asthma and allergic sensitisation in the International Study on Allergies and Asthma in Childhood (ISAAC) Phase Two.

Collaborators (149)

Weiland SK, Büchele G, Dentler C, Kleiner A, Rzehak P, Weinmayr G, Priftanji A, Shkurti A, Simenati J, Grabocka E, Shyti K, Agolli S, Gurakuqi A, Stein RT, Urrutia de Pereira M, Jones MH, Pitrez PM, Cooper PJ, Chico M, Chen YZ, Zhong NS, Lai CK, Wong GW, Riikjärv MA, Annus T, Annesi-Maesano I, Gotua M, Rukhadze M, Abramidze T, Kvachadze I, Karsanidze L, Kiladze M, Dolidze N, Leupold W, Keil U, von Mutius E, Weiland SK, von Mutius E, Keil U, Weiland SK, Arthur P, Addo-Yobo E, Gratziou C, Priftis K, Papadopoulou A, Katsardis C, Tsanakas J, Hatziagorou E, Kirvassilis F, Clausen M, Shah JR, Mathur RS, Khubchandani RP, Mantri S, Forastiere F, Di Domenicantonio R, De Sario M, Sammarro S, Pistelli R, Serra MG, Corbo G, Perucci CA, Svabe V, Sebre D, Casno G, Novikova I, Bagrade L, Brunekreef B, Schram D, Doekes G, Jansen-van Vliet PH, Janssen NA, Aarts FJ, de Meer G, Crane J, Wickens K, Barry D, Nystad W, Bolle R, Lund E, Batlles Garrido J, Rubi Ruiz T, Bonillo Perales A, Gonzalez Jiménez Y, Aguirre Rodriguez J, Momblan de Cabo J, Losilla Maldonado A, Daza Torres M, García-Marcos L, Martinez Torres A, Guillén Pérez JJ, Piñana López A, Castejon Robles S, García Hernandez G, Martinez Gimeno A, Moro Rodríguez AL, Luna Paredes C, Gonzalez Gil I, Morales Suarez-Varela MM, Llopis González A, Escribano Montaner A, Tallon Guerola M, Bråbãck L, Kjellman M, Nilsson L, Mai XM, Bråbãck L, Sandin A, Saraçlar Y, Kuyucu S, Tuncer A, Saçkesen C, Sumbulŏglu V, Geyik P, Kocabas C, Strachan DP, Kaur B, El-Sharif N, Nemery B, Barghuthy F, Abu Huij S, Qlebo M, Aït-Khaled N, Anderson HR, Strachan DP, Flohr C, Williams H, Forastiere F, Asher I, Ellwood P, Stewart A, Mitchell E, Crane J, Pearce N, Beasley R, Björkstén B, Brunekreef B, Foliaki S, García-Marcos L, Keil U, von Mutius E, Weiland SK, Weinmayr G, Lai CK, Wong GW, Mallol J, Montefort S, Odhiambo J, Robertson C.

Abstract

BACKGROUND:

The increasing prevalence of asthma and allergy might be related to diet, particularly in Western countries. A study was undertaken to assess the association between dietary factors, asthma and allergy in a large international study including objective measurements of atopy.

METHODS:

Between 1995 and 2005, cross-sectional studies were performed in 29 centres in 20 countries. Parental questionnaires were used to collect information on allergic diseases and exposure factors and data from 50 004 randomly selected schoolchildren (8-12 years, 29 579 with skin prick testing) were analysed. Random effect models for meta-analysis were applied to calculate combined ORs.

RESULTS:

Fruit intake was associated with a low prevalence of current wheeze in affluent (OR(adj) 0.86, 95% CI 0.73 to 1.02) and non-affluent countries (OR(adj) 0.71, 95% CI 0.57 to 0.88). Consumption of fish in affluent countries (OR(adj) 0.85, 95% CI 0.74 to 0.97) and of cooked green vegetables in non-affluent countries (OR(adj) 0.78, 95% CI 0.65 to 0.95) was associated with a lower prevalence of current wheeze. Overall, more frequent consumption of fruit, vegetables and fish was associated with a lower lifetime prevalence of asthma, whereas high burger consumption was associated with higher lifetime asthma prevalence. None of the food items was associated with allergic sensitisation. Except for fruit juice and fruit consumption, no associations were found with atopic wheeze. Food selection according to the 'Mediterranean diet' was associated with a lower prevalence of current wheeze and asthma ever (p(trend)=0.03).

CONCLUSION:

Diet is associated with wheeze and asthma but not with allergic sensitisation in children. These results provide further evidence that adherence to the 'Mediterranean diet' may provide some protection against wheeze and asthma in childhood.

PMID:
20522849
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk