Curr Opin Mol Ther. 2010 Jun;12(3):294-304.

Progress toward genetic tailoring of heart failure therapy.

Source

Henry Ford Hospital, Heart and Vascular Institute, Section of Advanced Heart Failure and Cardiac Transplantation, 2799 West Grand Boulevard, Detroit, MI 48202, USA.

Abstract

Heart failure (HF) is a modern epidemic and a heterogeneous disorder with many therapeutic options. While the average response to each individual treatment is favorable, significant interindividual variation exists in the response to HF therapeutics. As a result, the optimal regimen for an individual patient or subgroup of patients is elusive, with current treatment being mainly empirical. Pharmacogenetic customization of HF therapy may provide an important opportunity to improve the treatment of HF. Common genetic variations exist in genes related to most classes of HF drugs, many of which have known functional consequences for or established relationships with drug response. This review summarizes the current understanding of the pharmacogenetics of HF therapeutics, including angiotensin-converting enzyme inhibitors and beta-blockers, and focuses on recent advances and medium-term expectations for the field.

PMID:: 20521218; [PubMed - indexed for MEDLINE]
PMCID:: PMC3048822

Free PMC Article

Images from this publication.See all images (2) Free text

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

Review

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Medical

Heart Failure - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Review Pharmacogenetics in heart failure: genomic markers of endothelial and neurohumoral function. [Congest Heart Fail. 2004]
Review Pharmacogenetics in heart failure: genomic markers of endothelial and neurohumoral function.
McNamara DM. Congest Heart Fail. 2004 Nov-Dec; 10(6):302-8.
Review Heart failure pharmacogenetics: past, present, and future. [Curr Cardiol Rep. 2011]
Review Heart failure pharmacogenetics: past, present, and future.
Davis HM, Johnson JA. Curr Cardiol Rep. 2011 Jun; 13(3):175-84.
Review Chronic heart failure: beta-blockers and pharmacogenetics. [Eur J Clin Pharmacol. 2009]
Review Chronic heart failure: beta-blockers and pharmacogenetics.
Azuma J, Nonen S. Eur J Clin Pharmacol. 2009 Jan; 65(1):3-17. Epub 2008 Oct 7.
Effects of ACE inhibitors or beta-blockers in patients treated with the fixed-dose combination of isosorbide dinitrate/hydralazine in the African-American Heart Failure Trial. [Am J Cardiovasc Drugs. 2007]
Effects of ACE inhibitors or beta-blockers in patients treated with the fixed-dose combination of isosorbide dinitrate/hydralazine in the African-American Heart Failure Trial.
Ghali JK, Tam SW, Ferdinand KC, Lindenfeld J, Sabolinski ML, Taylor AL, Worcel M, Curry CL, Cohn JN, A-HeFT Investigators. Am J Cardiovasc Drugs. 2007; 7(5):373-80.
Review Pharmacogenetics in heart failure: promises and challenges. [Expert Opin Pharmacother. 2009]
Review Pharmacogenetics in heart failure: promises and challenges.
de Boer RA, van der Harst P, van Veldhuisen DJ, van den Berg MP. Expert Opin Pharmacother. 2009 Aug; 10(11):1713-25.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Free in PMC
Free full text articles in PMC

Recent activity

Clear Turn Off Turn On

Progress toward genetic tailoring of heart failure therapy.
Progress toward genetic tailoring of heart failure therapy.
Curr Opin Mol Ther. 2010 Jun ;12(3):294-304.

PubMed
Epithelial mesenchymal transition traits in human breast cancer cell lines paral...
Epithelial mesenchymal transition traits in human breast cancer cell lines parallel the CD44(hi/)CD24 (lo/-) stem cell phenotype in human breast cancer.
J Mammary Gland Biol Neoplasia. 2010 Jun ;15(2):235-52. Epub 2010 Jun 4 .

PubMed
Quantum simulation of frustrated Ising spins with trapped ions.
Quantum simulation of frustrated Ising spins with trapped ions.
Nature. 2010 Jun 3 ;465(7298):590-3.

PubMed
Incidence of adverse events and negligence in hospitalized patients.
Incidence of adverse events and negligence in hospitalized patients.
N Engl J Med. 1991 Jul 18 ;325(3):210.

PubMed
Postprandial remodeling of the gut microbiota in Burmese pythons.
Postprandial remodeling of the gut microbiota in Burmese pythons.
ISME J. 2010 Nov ;4(11):1375-85. Epub 2010 Jun 3 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: