Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Aging (Albany NY). 2010 May;2(5):265-73.

Why men age faster but reproduce longer than women: mTOR and evolutionary perspectives.

Author information

  • 1Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA. blagosklonny@oncotarget.com

Abstract

Women live longer than men. Yet, it is believed that men do not age faster than women but simply are weaker at every age. In contrast, I discuss that men age faster. From evolutionary perspective, high accidental death rate in young males is compatible with fast aging. Mechanistically, hyper-activated mTOR (Target of Rapamycin) may render young males robust at the cost of accelerated aging. But if women age slower, why then is it women who have menopause? Some believe that menopause is programmed and purposeful (grandmother theory). In contrast, I discuss how menopause is not programmed but rather is an aimless continuation of the same program that initially starts reproduction at puberty. This quasi-program causes over-activation of female reproductive system, which is very vulnerable to over-activation. Mechanisms of aging and menopause are discussed.

PMID:
20519781
[PubMed - indexed for MEDLINE]
PMCID:
PMC2898017
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Impact Journals, LLC Icon for PubMed Central
    Loading ...
    Write to the Help Desk