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J Clin Endocrinol Metab. 2010 Aug;95(8):3918-25. doi: 10.1210/jc.2009-2516. Epub 2010 Jun 2.

The effect of training status on the metabolic response of bone to an acute bout of exhaustive treadmill running.

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  • 1Human Protection and Performance Enhancement, Room G077, Building A54, QinetiQ, Cody Technology Park, Ively Road, Farnborough, Hampshire GU14 0LX, United Kingdom. jscott1@qinetiq.com

Abstract

CONTEXT:

Strenuous exercise increases bone resorption but not formation. The effect of improved training status is unknown.

OBJECTIVE:

Our objective was to examine the metabolic response of bone to strenuous running in recreationally active (RA) and endurance-trained (ET) men.

DESIGN:

Eleven RA, 10 ET, and 10 control (CON) subjects completed one 8-d trial. On d 4, RA and ET completed an exhaustive treadmill run. Blood was obtained at baseline (BASE), during exercise, during 2 h of recovery, and on four follow-up (FU) days (FU1-FU4). CON rested throughout, providing blood samples at BASE and on FU1-FU4. Markers of bone resorption [C-terminal telopeptide region of collagen type 1 (beta-CTX)] and bone formation [N-terminal propeptides of procollagen type 1 (P1NP) and bone alkaline phosphatase (ALP)], osteoprotegerin (OPG), PTH, albumin-adjusted calcium (ACa), and phosphate (PO4) were measured.

RESULTS:

There were no significant differences between ET and RA and no changes in CON for any variable. Exercise increased beta-CTX at FU1-FU4 (P<0.001) but had no effect on P1NP or bone ALP. OPG was increased after 20 min of exercise (P<0.001) and remained elevated at FU1 (P<0.001). PTH, ACa, and PO4 were increased throughout exercise (P<0.01). ACa and PO4 remained elevated in the 2 h after exercise (P<0.001), whereas PTH was lower than BASE from 1-2 h after exercise (P<0.001).

CONCLUSION:

After acute, exhaustive running, bone resorption but not formation was increased for 4 d in RA and ET men. The increased bone resorption might be related to the increase in PTH, whereas increased OPG might be a compensatory response to increased bone resorption. Training status did not significantly affect the metabolic response of bone to exhaustive running.

PMID:
20519353
[PubMed - indexed for MEDLINE]
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