Breast Cancer Res. 2010;12(3):107. Epub 2010 Jun 1.

What do we learn from HER2-positive breast cancer genomic profiles?

Abstract

Patients with a tumor presenting amplification of the HER2 gene are currently proposed trastuzumab (herceptin) and this has greatly changed their outcome. However, a number of HER2-positive cancers show intrinsic or acquired resistance to trastuzumab and there are clear indications that they form a heterogeneous group of tumors. A paper in this issue of Breast Cancer Research addresses this heterogeneity at the genomic level.

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Breast Cancer Res. 2010;12(3):R25.

PMID:: 20519027; [PubMed - indexed for MEDLINE]
PMCID: PMC2917015

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