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Opt Lett. 2010 Jun 1;35(11):1804-6. doi: 10.1364/OL.35.001804.

Focal modulation microscopy: a theoretical study.

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  • 1Division of Bioengineering, National University of Singapore, 9 Engineering Drive 1, #EA-03-12, Singapore 129789.


Focal modulation microscopy is an emerging fluorescence microscopy technique for in vivo imaging of thick biological tissues. Here, we present a theoretical study to assess its performance. The scalar diffraction theory is combined with Monte Carlo simulation to evaluate the signal-to-background ratio at various depths. The performance of confocal microscopy with a similar optical setup is also evaluated for comparison.

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