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    Cardiology. 2010 Jul;116(2):79-88. Epub 2010 Jun 2.

    Age-dependent prognostic significance of atrial fibrillation in outpatients with chronic heart failure: data from the Italian Network on Congestive Heart Failure Registry.

    Baldasseroni S, Orso F, Fabbri G, De Bernardi A, Cirrincione V, Gonzini L, Fumagalli S, Marchionni N, Midi P, Maggioni AP; Italian Network on Congestive Heart Failure Investigators.

    Collaborators (233)
    Mezzani A, Bielli M, Milanese U, Ugliengo G, Pozzi R, Rabajoli F, Bosimini E, Begliuomini G, Ferrari A, Barzizza F, Valsecchi MG, Dadda F, Faggiano P, Castiglioni G, Gibelli G, Turelli AL, Belluschi R, Bianchi C, Emanuelli C, Gramenzi S, Foti G, Agnelli D, Mascioli G, Cazzani E, Zanelli E, Domenighini D, Castelli C, Moroni E, Gara E, Guzzetti S, Muzzupappa S, Turiel M, Cappiello E, Sandrone G, Recalcati F, Valenti D, Achilli F, Vincenzi A, Rusconi F, Palvarini M, Ghio S, Fontana A, Giusti A, Scelsi L, Sebastiani R, Ceresa M, Ferrari A, Nassiacos D, Meloni S, Nicoli T, Bandini P, Pedretti R, Paolucci M, Amati L, Ravetta M, Morandi F, Provasoli S, Bertolini A, Imperiale D, Agen W, Planca E, Quorso P, Ferro A, Pedrolli C, Russo P, Tarantini L, Candelpergher G, Cannarozzo PP, De Cian F, Agnoli A, Stefanini MG, Cacciavillani L, Boffa GM, Mario L, Renosto G, Stritoni P, Varotto L, Penzo M, Perini G, Giuliano G, Barducci E, Piazza R, Albanese MC, Fresco C, Picco F, Venturini P, Camerini A, Griffo R, Derchi G, Delfino L, Pizzorno L, Mazzantini S, Torre F, Orlandi S, Bertoli D, Gentile A, Naccarella F, Gatti M, Coluccini M, Morgagni G, Alfano G, Reggianini L, Sansoni S, Serra W, Passerini F, Del Corso P, Rusconi L, Marzaloni M, Mezzetti M, Gambarati GP, Mariani PR, Volterrani C, Venturi F, Zambaldi G, Casolo G, Moschi G, Geri Brandinelli A, Miracapillo G, Boni A, Italiani G, Vergoni W, Paci AM, Lattanzi F, Reisenhofer B, Severini D, Taddei T, Dalle Luche A, Comella A, Gasperini U, Cocchieri M, Alunni G, Bosi E, Panciarola R, Maragoni G, Bardelli G, Testarmata P, Pasetti L, Budini A, Gabrilelli D, Coderoni B, Midi P, Romaniello C, Del Sindaco D, Leggio F, Terranova A, Pulignano G, Pozzar F, Ansalone G, Magris B, Giannantoni P, Cacciatore G, Bottero G, Scaffidi G, Valtorta C, Salustri A, Amaddeo F, Barbato G, Aspromonte N, Baldo V, Baldo E, Frattaroli C, Mariani A, Di Marco G, Levantesi G, Potena AP, Colonna N, Montano A, Sensale P, Maiolica P, Somelli A, Napolitano F, Provvisiero P, Bottiglieri P, Ciriello N, Angelini E, Andriulo C, De Santis F, Cocco F, Zecca A, Pennetta A, Mariello F, Magliari F, De Giorgi A, Callerame M, Santoro V, Pede S, Renna A, De Donno O, De Lorenzi E, Polimeni G, Russo VA, Mangia R, Truncellito L, Cariello FP, Affinita M, Perticone F, Cloro C, Borelli D, Matta M, Lopresti D, Misuraca G, Caporale R, Chiappetta P, Tripodi E, Tassone F, Salituri S, Errigo C, Meringolo G, Donnangelo L, Canonico G, Coco R, Franco M, Coglitore A, Donato A, Di Tano G, Cento D, De Gregorio C, Mongiovì M, Schillaci AM, Mirto U, Clemenza F, Ingrillì F, Cavallaro A, Aloisi B, Ledda G, Rizzo C, Porcu M, Salis S, Pistis L, Pili G, Piras S, Maoddi I, Uras F.

    Italian Association of Hospital Cardiologists Research Center, University School of Medicine, Florence, Italy.

    Abstract

    OBJECTIVES: The role of atrial fibrillation (AF) in older patients with heart failure (HF) is controversial because many variables seem to influence their outcome. We investigated the predictivity of AF in 3 age groups of outpatients with HF.

    METHODS: We analyzed 8,178 outpatients enrolled in the Italian Network on Congestive Heart Failure Registry with HF diagnosed according to the European Society of Cardiology criteria. A trained cardiologist established the diagnosis of AF and HF at the entry visit at each center. We stratified the population into 3 age groups, as follows: group A, < or =65 years; group B, 66-75 years, and group C, >75 years.

    RESULTS: Group A was composed of 4,261 patients, 683 with AF (16.0%); in group B there were 2,651 patients, 638 with AF (24.1%), and group C was composed of 1,266 patients, 412 with AF (32.5%). The 1-year mortality rate was higher in AF patients in all groups. In a multivariate model, AF remained an independent risk factor for death in groups A and B, but not in group C [group A: hazard ratio (HR) 1.42, 95% confidence interval (CI) 1.10-1.81; group B: HR 1.29, 95% CI 1.00-1.67; group C: HR 1.05, 95% CI 0.78-1.43].

    CONCLUSION: The prevalence of AF increased with age and was associated with a higher mortality rate. However, AF independently predicted all-cause mortality only in patients aged < or =75 years.

    PMID: 20516683 [PubMed - in process]

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