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Antivir Ther. 2010;15(3 Pt B):499-503. doi: 10.3851/IMP1494.

HIV-HBV coinfection among South African patients receiving antiretroviral therapy.

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  • 1Department of Internal Medicine, Saint Louis University, St Louis, MO, USA. dibiscam@slu.edu


There are approximately 33 million individuals with HIV infection worldwide. The majority of infections are in southern Africa where hepatitis B is also known to be endemic. As access to life-saving antiretroviral therapy (ART) increases, the possibility for hepatitis B treatment resistance increases because most ART regimens contain lamivudine. Patients coinfected with HBV are therefore receiving monotherapy for HBV infection, leading to possible HBV-resistant mutants and the concurrent public health effect thereof. Additional information is needed on the prevalence of HIV-HBV coinfection and treatment response to ART. We present a summary of the information available from South Africa to date.

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