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Antivir Ther. 2010;15(3 Pt B):499-503. doi: 10.3851/IMP1494.

HIV-HBV coinfection among South African patients receiving antiretroviral therapy.

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  • 1Department of Internal Medicine, Saint Louis University, St Louis, MO, USA.


There are approximately 33 million individuals with HIV infection worldwide. The majority of infections are in southern Africa where hepatitis B is also known to be endemic. As access to life-saving antiretroviral therapy (ART) increases, the possibility for hepatitis B treatment resistance increases because most ART regimens contain lamivudine. Patients coinfected with HBV are therefore receiving monotherapy for HBV infection, leading to possible HBV-resistant mutants and the concurrent public health effect thereof. Additional information is needed on the prevalence of HIV-HBV coinfection and treatment response to ART. We present a summary of the information available from South Africa to date.

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