Format

Send to:

Choose Destination
See comment in PubMed Commons below
Endocrinol Metab Clin North Am. 2010 Jun;39(2):401-18, table of contents. doi: 10.1016/j.ecl.2010.02.011.

The role of vitamin D in cancer prevention and treatment.

Author information

  • 1Department of Medicine, Division of Endocrinology, Stanford University School of Medicine, Stanford, CA 94305-5103, USA.

Abstract

Calcitriol (1,25-dihydroxyvitamin D(3)), the hormonally active form of vitamin D, exerts growth inhibitory and prodifferentiating effects on many malignant cells and retards tumor growth in animal models. Calcitriol is being evaluated as an anticancer agent in several human cancers. The mechanisms underlying the anticancer effects of calcitriol include inhibition of cell proliferation, stimulation of apoptosis, suppression of inflammation, and inhibition of tumor angiogenesis, invasion, and metastasis. This review discusses some of the molecular pathways mediating these anticancer actions of calcitriol and the preclinical data in cell culture and animal models. The clinical trials evaluating the use of calcitriol and its analogues in the treatment of patients with cancer are described. The reasons for the lack of impressive beneficial effects in clinical trials compared with the substantial efficacy seen in preclinical models are discussed.

Copyright 2010 Elsevier Inc. All rights reserved.

Republished in

PMID:
20511060
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk