Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Endocrinol Metab Clin North Am. 2010 Jun;39(2):271-86, table of contents. doi: 10.1016/j.ecl.2010.02.012.

Assessment and interpretation of circulating 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D in the clinical environment.

Author information

  • Department of Biochemistry and Molecular Biology, Children's Research Institute, Medical University of South Carolina, Charleston, SC 29425, USA. hollisb@musc.edu

Abstract

The unique cis-triene structure of vitamin D and related metabolites makes it susceptible to oxidation, ultraviolet (UV) light-induced conformational changes, heat-induced conformational changes, and attacks by free radicals. Vitamin D(2) is much less bioactive than vitamin D(3) in humans. Metabolic activation and inactivation of vitamin D are well characterized and result in a plethora of metabolites, of which only 25-hydroxyvitamin D (25(OH)D) and 1,25-dihydroxyvitamin D (1,25(OH)(2)D) provide any clinically relevant information. 25(OH)D(2) and 25(OH)D(3) are commonly known as calcifediol and the 1,25(OH)(2)D metabolites as calcitriol. In this review the current state of the science on the clinical assessment of circulating 25(OH)D and 1,25(OH)(2)D is described.

Copyright 2010 Elsevier Inc. All rights reserved.

PMID:
20511051
[PubMed - indexed for MEDLINE]
PMCID:
PMC2903449
Free PMC Article

Images from this publication.See all images (1)Free text

Fig. 1
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk