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Burns. 2010 Dec;36(8):1222-7. doi: 10.1016/j.burns.2010.03.002. Epub 2010 May 26.

Enhanced neovascularization of dermis substitutes via low-pressure plasma-mediated surface activation.

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  • 1Department of Plastic and Hand Surgery, Burn Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Buerkle-de-la-Camp Platz 1, 44789 Bochum, Germany.



The effect of cold low-pressure plasma treatment on neovascularization of a dermis substitute was evaluated in a mouse model.


Collagen-elastin matrices (Matriderm(®)) were used as scaffolds. Low-pressure argon/hydrogene plasma-treated scaffolds were transplanted into the dorsal skinfold chambers of balb/c mice (group 1, n=10). Untreated scaffolds served as controls (group 2, n=10). Intravital fluorescence microscopy was performed within the border zone of the scaffolds on days 1, 5 and 10. Functional vessel density (FVD), vessel diameter, intervascular distance, microvascular permeability, and leukocyte-endothelium interaction were analyzed.


An increase of FVD associated with a reduction of the intervascular distance was observed. Statistical analysis revealed that the functional vessel density in the border zone of the scaffolds was significantly enhanced in the plasma-treated group compared to controls. For group 1, an increase of FVD from 282±8 cm/cm(2) on days 5 to 315±8 cm/cm(2) on day 10 was observed. Whereas values of 254±7 cm/cm(2) on day 5 and 275±13 cm/cm(2) on day 10 have resulted in group 2 (mean±S.E.M., Student's t-test, p<0.05).


The surface treatment by cold low-pressure plasma intensifies the angiogenesis and accelerates the neovascularization of collagen-elastin matrix.

Copyright © 2010 Elsevier Ltd and ISBI. All rights reserved.

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