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J Clin Virol. 2010 May;48 Suppl 1:S14-9. doi: 10.1016/S1386-6532(10)70004-4.

Prevention strategies for herpes zoster and post-herpetic neuralgia.

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  • 1Pediatric Infectious Diseases, University of Colorado Denver, Mail Stop C227, Building 401, 1784 Racine Street, Room R09-108, Aurora, CO 80045, USA.


Impairment of varicella zoster virus (VZV)-specific cell-mediated immunity, including impairment due to immunosenescence, is associated with an increased risk of developing herpes zoster (HZ), whereas levels of anti-VZV antibodies do not correlate with HZ risk. This crucial role of VZV-specific cell-mediated immunity suggests that boosting these responses by vaccination will be an effective strategy for reducing the burden of HZ. Other strategies focus on preventing the major complication of HZ--post-herpetic neuralgia. These strategies include pre-emptive treatment with drugs such as tricyclic antidepressants, anticonvulsants and analgesics.

2010 Elsevier B.V. All rights reserved.

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