Nucleic Acids Res. 2010 Jul;38(Web Server issue):W540-4. Epub 2010 May 27.

FoXS: a web server for rapid computation and fitting of SAXS profiles.

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Department of Bioengineering and Therapeutic Sciences, University of California at San Francisco, CA 94158, USA.

Abstract

Small angle X-ray scattering (SAXS) is an increasingly common technique for low-resolution structural characterization of molecules in solution. SAXS experiment determines the scattering intensity of a molecule as a function of spatial frequency, termed SAXS profile. SAXS profiles can contribute to many applications, such as comparing a conformation in solution with the corresponding X-ray structure, modeling a flexible or multi-modular protein, and assembling a macromolecular complex from its subunits. These applications require rapid computation of a SAXS profile from a molecular structure. FoXS (Fast X-Ray Scattering) is a rapid method for computing a SAXS profile of a given structure and for matching of the computed and experimental profiles. Here, we describe the interface and capabilities of the FoXS web server (http://salilab.org/foxs).

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PMCID:: PMC2896111

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