Protein Sci. 2010 Jul;19(7):1432-8.

The structure of the FYR domain of transforming growth factor beta regulator 1.

García-Alai MM, Allen MD, Joerger AC, Bycroft M.

Source

MRC Centre for Protein Engineering, Hills Road, Cambridge CB2 0QH, United Kingdom.

Abstract

Many chromatin-associated proteins contain two sequence motifs rich in phenylalanine/tyrosine residues of unknown function. These so-called FYRN and FYRC motifs are also found in transforming growth factor beta regulator 1 (TBRG1)/nuclear interactor of ARF and MDM2 (NIAM), a growth inhibitory protein that also plays a role in maintaining chromosomal stability. We have solved the structure of a fragment of TBRG1, which encompasses both of these motifs. The FYRN and FYRC regions each form part of a single folded module (the FYR domain), which adopts a novel alpha + beta fold. Proteins such as the histone H3K4 methyltransferases trithorax and mixed lineage leukemia (MLL), in which the FYRN and FYRC regions are separated by hundreds of amino acids, are expected to contain FYR domains with a large insertion between two of the strands of the beta-sheet.

PMID:: 20506279; [PubMed - indexed for MEDLINE]
PMCID:: PMC2970912

Free PMC Article

Images from this publication.See all images (3) Free text

MeSH Terms, Substances, Secondary Source ID

MeSH Terms

Substances

Secondary Source ID

PDB/2WZO

LinkOut - more resources

Full Text Sources

Supplemental Content

Save items

Related citations in PubMed

Amino acid requirements for formation of the TGF-beta-latent TGF-beta binding protein complexes. [J Mol Biol. 2005]
Amino acid requirements for formation of the TGF-beta-latent TGF-beta binding protein complexes.
Chen Y, Ali T, Todorovic V, O'leary JM, Kristina Downing A, Rifkin DB. J Mol Biol. 2005 Jan 7; 345(1):175-86.
Packing, specificity, and mutability at the binding interface between the p160 coactivator and CREB-binding protein. [Protein Sci. 2004]
Packing, specificity, and mutability at the binding interface between the p160 coactivator and CREB-binding protein.
Demarest SJ, Deechongkit S, Dyson HJ, Evans RM, Wright PE. Protein Sci. 2004 Jan; 13(1):203-10.
Defining the molecular basis of Arf and Hdm2 interactions. [J Mol Biol. 2001]
Defining the molecular basis of Arf and Hdm2 interactions.
Bothner B, Lewis WS, DiGiammarino EL, Weber JD, Bothner SJ, Kriwacki RW. J Mol Biol. 2001 Nov 23; 314(2):263-77.
Review The PWWP domain: a potential protein-protein interaction domain in nuclear proteins influencing differentiation? [FEBS Lett. 2000]
Review The PWWP domain: a potential protein-protein interaction domain in nuclear proteins influencing differentiation?
Stec I, Nagl SB, van Ommen GJ, den Dunnen JT. FEBS Lett. 2000 May 4; 473(1):1-5.
Review [A turning point in the knowledge of the structure-function-activity relations of elastin]. [J Soc Biol. 2001]
Review [A turning point in the knowledge of the structure-function-activity relations of elastin].
Alix AJ. J Soc Biol. 2001; 195(2):181-93.

See reviews... See all...

Cited by 3 PubMed Central articles

The HARE-HTH and associated domains: novel modules in the coordination of epigenetic DNA and protein modifications. [Cell Cycle. 2012]
The HARE-HTH and associated domains: novel modules in the coordination of epigenetic DNA and protein modifications.
Aravind L, Iyer LM. Cell Cycle. 2012 Jan 1; 11(1):119-31. Epub 2012 Jan 1.
Mutation spectrum of MLL2 in a cohort of Kabuki syndrome patients. [Orphanet J Rare Dis. 2011]
Mutation spectrum of MLL2 in a cohort of Kabuki syndrome patients.
Micale L, Augello B, Fusco C, Selicorni A, Loviglio MN, Silengo MC, Reymond A, Gumiero B, Zucchetti F, D'Addetta EV, et al. Orphanet J Rare Dis. 2011 Jun 9; 6:38. Epub 2011 Jun 9.
Review The super elongation complex (SEC) and MLL in development and disease. [Genes Dev. 2011]
Review The super elongation complex (SEC) and MLL in development and disease.
Smith E, Lin C, Shilatifard A. Genes Dev. 2011 Apr 1; 25(7):661-72.

Structures reported by this article

The Structure Of The Fyr Domain

PDB: 2WZO

Source: Homo sapiens

Method: X-Ray Diffraction

Resolution: 1.6 Å

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
Gene (GeneRIF)
Gene records that have the current articles as Reference into Function citations (GeneRIFs). NLM staff reviewing the literature while indexing MEDLINE add GeneRIFs manually.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
Nucleotide
Primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
UniGene
UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.
Protein
Protein translation features of primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
Structure
Three-dimensional structure records in the NCBI Structure database for data reported in the current articles.
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

The structure of the FYR domain of transforming growth factor beta regulator 1.
The structure of the FYR domain of transforming growth factor beta regulator 1.
Protein Sci. 2010 Jul ;19(7):1432-8.

PubMed
Inhibition of notch signaling in glioblastoma targets cancer stem cells via an e...
Inhibition of notch signaling in glioblastoma targets cancer stem cells via an endothelial cell intermediate.
Stem Cells. 2010 Jun ;28(6):1019-29.

PubMed
Longitudinal study of semen quality of unexposed workers. Sperm motility charact...
Longitudinal study of semen quality of unexposed workers. Sperm motility characteristics.
J Androl. 1991 Mar-Apr ;12(2):126-31.

PubMed
Effects of multidisciplinary Internet-based program on management of heart failu...
Effects of multidisciplinary Internet-based program on management of heart failure.
J Multidiscip Healthc. 2008 Dec 1;2009(2):13-21.

PubMed
Convergence in probiotic Lactobacillus gut-adaptive responses in humans and mice...
Convergence in probiotic Lactobacillus gut-adaptive responses in humans and mice.
ISME J. 2010 Nov ;4(11):1481-4. Epub 2010 May 27 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: