Format

Send to

Choose Destination
See comment in PubMed Commons below
J Cell Physiol. 2010 Oct;225(1):15-9. doi: 10.1002/jcp.22251.

The culture and transplantation of human limbal stem cells.

Author information

  • 1Institute of Human Genetics, Newcastle University, Newcastle upon Tyne, United Kingdom. sajjad.ahmad@ncl.ac.uk

Abstract

The cornea is the clear front of the eye and its surface is composed of an epithelium. This is renewed by stem cells located at the limbus, which encircles the periphery of the cornea. These limbal stem cells become lost or deficient in the blinding disease of limbal stem cell deficiency. In this review article, we discuss the historical perspective in managing limbal stem cell deficiency as well as describing the more contemporary treatment options, and in particular the culture and transplantation of human limbal stem cells. This treatment was first proposed 13 years ago and many case series have been presented to date showing promising outcomes of this technique. However, challenges still remain in treating the debilitating disease of limbal stem cell deficiency. Here we discuss some of the questions, which remain to be answered in this field.

(c) 2010 Wiley-Liss, Inc.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Write to the Help Desk