Format

Send to:

Choose Destination
See comment in PubMed Commons below
Cancer Epidemiol Biomarkers Prev. 2010 Jun;19(6):1468-70. doi: 10.1158/1055-9965.EPI-10-0012. Epub 2010 May 25.

Esophageal adenocarcinoma incidence: are we reaching the peak?

Author information

  • 1The VA Outcomes Group, Veterans Affairs Medical Center, White River Junction, Vermont 05009, USA. heiko.pohl@dartmouth.edu

Erratum in

  • Cancer Epidemiol Biomarkers Prev. 2010 Sep;19(9):2416.

Abstract

BACKGROUND:

A steep increase in the incidence of esophageal adenocarcinoma has been observed between 1973 and 2001, but recent trends have not been reported. Our aim was to examine recent trends in esophageal adenocarcinoma incidence.

METHODS:

We used the Surveillance Epidemiology and End Results database of the National Cancer Institute to identify all patients who were diagnosed with esophageal adenocarcinoma between 1973 and 2006. Incidence trends were analyzed for esophageal adenocarcinoma overall and by stage using joinpoint regression.

RESULTS:

Overall esophageal adenocarcinoma incidence increased from 3.6 per million in 1973 to 25.6 per million in 2006. Incidence trend analysis, however, suggests that the increase has slowed, from an 8.2% annual increase prior to 1996 to 1.3% increase in subsequent years (P = 0.03). Stage-specific trend analyses suggest that the change in overall esophageal adenocarcinoma incidence largely reflects a plateau in the incidence of early stage disease. Its slope has changed direction, from a 10% annual increase prior to 1999 to a 1.6% decline in subsequent years (P = 0.01).

CONCLUSIONS:

The incidence of early stage esophageal adenocarcinoma seems to have plateaued.

IMPACT:

Although definitive conclusions will require additional years of data, the plateau in early stage disease might portend stabilization in the overall incidence of esophageal adenocarcinoma.

Copyright 2010 AACR.

PMID:
20501776
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk