Bioinformatics. 2010 Jul 15;26(14):1804-5. Epub 2010 May 25.

GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base.

Khelashvili G, Dorff K, Shan J, Camacho-Artacho M, Skrabanek L, Vroling B, Bouvier M, Devi LA, George SR, Javitch JA, Lohse MJ, Milligan G, Neubig RR, Palczewski K, Parmentier M, Pin JP, Vriend G, Campagne F, Filizola M.

Source

Department of Physiology & Biophysics, Weill Medical College of Cornell University, New York, NY, USA.

Abstract

SUMMARY: Rapid expansion of available data about G Protein Coupled Receptor (GPCR) dimers/oligomers over the past few years requires an effective system to organize this information electronically. Based on an ontology derived from a community dialog involving colleagues using experimental and computational methodologies, we developed the GPCR-Oligomerization Knowledge Base (GPCR-OKB). GPCR-OKB is a system that supports browsing and searching for GPCR oligomer data. Such data were manually derived from the literature. While focused on GPCR oligomers, GPCR-OKB is seamlessly connected to GPCRDB, facilitating the correlation of information about GPCR protomers and oligomers. Availability and Implementation: The GPCR-OKB web application is freely available at http://www.gpcr-okb.org

PMID:: 20501551; [PubMed - indexed for MEDLINE]
PMCID: PMC2894509

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Publication Types, MeSH Terms, Substances, Grant Support

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MeSH Terms

Substances

Receptors, G-Protein-Coupled

Grant Support

DA017976/DA/NIDA NIH HHS/United States

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