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Clin Otolaryngol. 2010 Apr;35(2):118-24. doi: 10.1111/j.1749-4486.2010.02085.x.

Treatment and prognostic factors of papillary thyroid microcarcinoma.

Author information

  • 1Department of Otorhinolaryngology, University Hospital of Parma, 43100 Parma, Italy. davidegiordano76@hotmail.com

Abstract

OBJECTIVE:

To discuss the prognostic factors and outcomes of treatment in patients diagnosed with papillary thyroid microcarcinoma.

DESIGN:

Retrospective observational case review.

SETTING:

Department of Otorhinolaryngology of the tertiary referral teaching hospital of Parma.

PARTICIPANTS:

Ninety-seven patients diagnosed with PTMC and surgically treated between January 1998 and December 2007.

MAIN OUTCOME MEASURES:

Clinical and histopathological characteristics of the study group were identified and statistically analysed.

RESULTS:

No cancer-related deaths were registered. Incidence of recurrent disease was 9% after a 43 month mean follow-up (range 12-120). Univariate analysis detected that metastases in neck lymph nodes at diagnosis (p = 0.025), a tumour >5 mm in size (p = 0.011), the presence of bilateral tumoural foci (p = 0.007), the presence of capsular invasion (p = 0.001), and the presence of vascular invasion (p = 0.004) were related to recurrent disease. On multivariate analysis, the presence of bilateral tumoural foci (p = 0.030), and the presence of capsular invasion (p = 0.005) were significantly related to tumour recurrence.

CONCLUSION:

The prognosis for patients with papillary thyroid microcarcinoma in this series was excellent, with a 100% survival rate and minimal surgical-related morbidity. Nevertheless, approximately 10% of patients developed recurrent disease; aggressive treatment may be justified depending on the presence or absence of prognostic risk factors.

PMID:
20500581
[PubMed - indexed for MEDLINE]
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