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Neurosurgery. 2010 Jun;66(6):E1206-7. doi: 10.1227/01.NEU.0000369196.94664.4E.

Parahippocampal corpora amylacea: case report.

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  • 1Department of Neurological Surgery, University of Washington, Seattle, Washington 98195, USA.

Abstract

OBJECTIVE:

Corpora amylacea (CA) normally accumulate within perivascular, subpial, and subependymal astrocytic processes. CA are associated with a number of conditions including normal aging, hippocampal sclerosis associated with temporal lobe epilepsy, multiple sclerosis, Lafora-type progressive myoclonic epilepsy, and adult polyglucosan body disease. Reports of massive localized accumulation of CA in the brain outside of these conditions are rare.

CLINICAL PRESENTATION:

A 49-year-old woman, with a long-standing history of migraine headaches, presented to her primary care provider for increased headache duration. Brain magnetic resonance imaging (MRI) revealed a left parahippocampal lesion, suggestive of low-grade glioma.

INTERVENTION:

Given the MRI suggestive of left parahippocampal glioma, left-sided frontotemporal craniotomy was performed for resection of the lesion. Specimens obtained during the operation revealed focal high-density accumulation of CA with no evidence of neoplasm, ischemia, or hypoxic injury.

CONCLUSION:

This case illustrates the possibility that localized high-density CA accumulation can present as an intrinsic lesion on brain MRI. CA should be included in the differential diagnosis for patients presenting with brain MRI suggestive of nonenhancing space-occupying lesions.

PMID:
20495392
[PubMed - indexed for MEDLINE]
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