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    Lancet Neurol. 2010 Jun;9(6):599-612. doi: 10.1016/S1474-4422(10)70086-7.

    Vitamin D and multiple sclerosis.

    Source

    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA. aascheri@hsph.harvard.edu

    Abstract

    The hypothesis that adequate vitamin D nutrition can contribute to the prevention of multiple sclerosis (MS) was originally proposed to explain the geographical distribution of MS, but only recently has the relation between various measures of vitamin D (eg, sun exposure, dietary sources, and serum concentrations of 25-hydroxyvitamin D) and risk of developing MS been rigorously investigated. Overall, the results of these studies support a protective effect of vitamin D, but there are uncertainties and many unanswered questions, including how vitamin D exerts a protective effect, how genetic variations modify the effect, and whether vitamin D can influence the course of MS progression.

    Copyright 2010 Elsevier Ltd. All rights reserved.

    Comment in

    PMID:
    20494325
    [PubMed - indexed for MEDLINE]

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