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Psychiatry Res. 2010 Jun 30;182(3):207-10. doi: 10.1016/j.pscychresns.2010.04.002. Epub 2010 May 20.

Functional connectivity between ventral prefrontal cortex and amygdala at low frequency in the resting state in bipolar disorder.

Author information

  • 1Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA. lara.chepenik@yale.edu

Abstract

Trait abnormalities in bipolar disorder (BD) within the ventral prefrontal cortex (vPFC) and the amygdala suggest dysfunction in their connectivity. This study employed low frequency resting state functional magnetic resonance imaging (LFRS-fMRI) to analyze functional connectivity between the vPFC and the amygdala in BD. LFRS-fMRI identified a negative correlation in vPFC-amygdala activity, and the magnitude of this correlation was greater in healthy participants than in subjects with BD. Additionally, whole-brain analysis revealed higher correlations between left and right vPFC in BD, as well as with ventral striatum.

PMID:
20493671
[PubMed - indexed for MEDLINE]
PMCID:
PMC2914819
Free PMC Article

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