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Psychiatry Res. 2010 Jul 30;178(2):433-6. doi: 10.1016/j.psychres.2010.04.048. Epub 2010 May 20.

COMT and anxiety and cognition in children with chromosome 22q11.2 deletion syndrome.

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  • 1Duke University Medical Center, Division of Medical Genetics, Department of Pediatrics, Durham, North Carolina 27710, USA. vandana.shashi@duke.edu

Abstract

The COMT gene is thought to contribute to the cognitive/psychiatric phenotypes in 22q11.2 deletion syndrome. We measured these manifestations against the Val/Met alleles of the COMT gene, in 40 nonpsychotic 22q11DS children. The Val allele was associated with poor IQ, processing speed, executive function and a higher frequency of anxiety disorders, underscoring the importance of the COMT gene in the childhood psychopathology in 22q11DS.

Copyright 2010 Elsevier Ireland Ltd. All rights reserved.

PMID:
20488547
[PubMed - indexed for MEDLINE]
PMCID:
PMC3645485
Free PMC Article
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